Assay Detail
Binding
CHEMBL839710
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Inhibition of [3H]8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.33 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362540 | — | — | 1 | 9.06 |
| CHEMBL186112 | — | — | 1 | 8.91 |
| CHEMBL186758 | — | — | 1 | 8.88 |
| CHEMBL188176 | — | — | 1 | 8.83 |
| CHEMBL186316 | — | — | 1 | 7.99 |
| CHEMBL184535 | — | — | 1 | 7.93 |
| CHEMBL28056 | — | — | 1 | 6.85 |
| CHEMBL182792 | — | — | 1 | 6.76 |
| CHEMBL361875 | — | — | 1 | 6.46 |
| CHEMBL273921 | — | — | 1 | 6.32 |
| CHEMBL314055 | — | — | 1 | 6.29 |
| CHEMBL362354 | — | — | 1 | 6.25 |
| CHEMBL361287 | — | — | 1 | 6.17 |
| CHEMBL363466 | — | — | 1 | 5.85 |
| CHEMBL184666 | — | — | 1 | - |
| CHEMBL183329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362540 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL186112 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL186758 | — | Ki | = | 1.31 | nM | 8.88 |
| CHEMBL188176 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL186316 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL184535 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL28056 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL182792 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL361875 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL273921 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL314055 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL362354 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL361287 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL363466 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL184666 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL183329 | — | Ki | > | 1000.0 | nM | - |