Compound Detail
CHEMBL361287
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Basic Information
| ChEMBL ID | CHEMBL361287 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VDFXNGPWAIBQSN-SFHVURJKSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
339.5
MW (Da)
4.79
ALogP
3
HBA
0
HBD
21.7
PSA (Ų)
0.72
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 6.44 | 6.44 | 364.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 6.17 | 6.17 | 680.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 5.68 | 5.68 | 2110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 364.0 | nM | 6.44 | Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor | 15267230 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 680.0 | nM | 6.17 | Inhibition of [3H]8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor | 15267230 |
| D(2) dopamine receptor | Ki | = | 2110.0 | nM | 5.68 | Inhibition of [3H]raclopride binding to Dopamine receptor D2A in rat | 15267230 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15267230 | 10.1021/jm0498102 | 5-hydroxytryptamine receptor 7 | 2 |
| 15267230 | 10.1021/jm0498102 | 5-hydroxytryptamine receptor 1A | 1 |
| 15267230 | 10.1021/jm0498102 | D(2) dopamine receptor | 1 |
| 15267230 | 10.1021/jm0498102 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine