Assay Detail
Binding
CHEMBL826383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]raclopride binding to Dopamine receptor D2A in rat
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.32 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186112 | — | — | 1 | 6.97 |
| CHEMBL273921 | — | — | 1 | 6.63 |
| CHEMBL363466 | — | — | 1 | 6.62 |
| CHEMBL28056 | — | — | 1 | 6.30 |
| CHEMBL186316 | — | — | 1 | 6.29 |
| CHEMBL186758 | — | — | 1 | 6.13 |
| CHEMBL361875 | — | — | 1 | 5.92 |
| CHEMBL361287 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186112 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL273921 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL363466 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL28056 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL186316 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL186758 | — | Ki | = | 741.0 | nM | 6.13 |
| CHEMBL361875 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL361287 | — | Ki | = | 2110.0 | nM | 5.68 |