Compound Detail
CHEMBL18980
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Basic Information
| ChEMBL ID | CHEMBL18980 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FLOJCNYYPGNYBP-NKWVEPMBSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
151.2
MW (Da)
0.88
ALogP
2
HBA
2
HBD
40.7
PSA (Ų)
0.63
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL5076 | Ki | 7.48 | 7.48 | 33.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 33.0 | nM | 7.48 | Binding affinity against Histamine H3 receptor | 7752184 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7752184 | 10.1021/jm00010a003 | Histamine H3 receptor | 2 |
| 7752184 | 10.1021/jm00010a003 | Histamine H1 receptor | 1 |
| 7752184 | 10.1021/jm00010a003 | Cavia porcellus | 1 |
| 10197963 | 10.1021/jm980408v | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine