Assay Detail
Binding
CHEMBL693575
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Binding affinity against Histamine H3 receptor
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.01 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277341 | — | — | 1 | 9.10 |
| CHEMBL268229 | — | — | 1 | 8.82 |
| CHEMBL18735 | — | — | 2 | 8.55 |
| CHEMBL40378 | — | — | 1 | 7.96 |
| CHEMBL18980 | — | — | 1 | 7.48 |
| CHEMBL289383 | — | — | 1 | 6.13 |
| CHEMBL37568 | — | — | 1 | - |
| CHEMBL289123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277341 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL268229 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL18735 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL18735 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL40378 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL18980 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL289383 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL37568 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL289123 | — | Ki | > | 2000.0 | nM | - |