Compound Detail
CHEMBL18735
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Basic Information
| ChEMBL ID | CHEMBL18735 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FLOJCNYYPGNYBP-RQJHMYQMSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
151.2
MW (Da)
0.88
ALogP
2
HBA
2
HBD
40.7
PSA (Ų)
0.63
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL5076 | Ki | 8.55 | 8.3767 | 2.8 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 2.8 | nM | 8.55 | Binding affinity against Histamine H3 receptor | 7752184 |
| Histamine H3 receptor | Ki | = | 3.0 | nM | 8.52 | Inhibition of [3H]N-alpha-methylhistamine binding to guinea pig brain Histamine ... | 9871662 |
| Histamine H3 receptor | Ki | = | 8.7 | nM | 8.06 | Binding affinity against Histamine H3 receptor | 7752184 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7752184 | 10.1021/jm00010a003 | Histamine H3 receptor | 3 |
| 7752184 | 10.1021/jm00010a003 | Histamine H1 receptor | 2 |
| 7752184 | 10.1021/jm00010a003 | Cavia porcellus | 2 |
| 15163206 | 10.1021/jm031141p | Cavia porcellus | 1 |
| 15163206 | 10.1021/jm031141p | Histamine H3 receptor | 1 |
| 9871662 | 10.1016/s0960-894x(98)00020-1 | Histamine H3 receptor | 1 |
| 9871662 | 10.1016/s0960-894x(98)00020-1 | Histamine H1 receptor | 1 |
| 10197963 | 10.1021/jm980408v | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine