Assay Detail
Binding
CHEMBL693572
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Inhibition of [3H]N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Trans-4-methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79983 | — | — | 1 | 8.70 |
| CHEMBL313127 | — | — | 1 | 8.64 |
| CHEMBL18735 | — | — | 1 | 8.52 |
| CHEMBL83271 | — | — | 1 | 8.52 |
| CHEMBL83917 | — | — | 1 | 8.30 |
| CHEMBL79271 | — | — | 1 | 8.15 |
| CHEMBL81888 | — | — | 1 | 7.23 |
| CHEMBL83862 | — | — | 1 | 7.12 |
| CHEMBL83325 | — | — | 1 | 6.82 |
| CHEMBL315572 | — | — | 1 | 6.77 |
| CHEMBL312664 | — | — | 1 | - |
| CHEMBL312613 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79983 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL313127 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL18735 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL83271 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL83917 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL79271 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL81888 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL83862 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL83325 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL315572 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL312664 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL312613 | — | Ki | > | 2000.0 | nM | - |