Compound Detail
CHEMBL1908306
EFLUCIMIBE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1908306 |
| Name | EFLUCIMIBE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ZXEIEKDGPVTZLD-NDEPHWFRSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
3
Known Names
Molecular Properties
469.7
MW (Da)
8.65
ALogP
3
HBA
2
HBD
49.3
PSA (Ų)
0.20
QED
1
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 5 meas. best 7.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 CHEMBL2782 | IC50 | 7.41 | 7.41 | 39.0 | 2 |
| Acetyl-CoA acetyltransferase, mitochondrial CHEMBL2616 | IC50 | 7.23 | 7.23 | 59.0 | 1 |
| Sterol O-acyltransferase 2 CHEMBL4465 | IC50 | 6.96 | 6.96 | 110.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 | IC50 | = | 39.0 | nM | 7.41 | Inhibition of ACAT1 (unknown origin) | - |
| Sterol O-acyltransferase 1 | IC50 | = | 39.0 | nM | 7.41 | Inhibition Assay: Methods for assessing the selectively of ACAT1 inhibitors are ... | - |
| Acetyl-CoA acetyltransferase, mitochondrial | IC50 | = | 59.0 | nM | 7.23 | Inhibition of ACAT1 (unknown origin) | 38569434 |
| Sterol O-acyltransferase 2 | IC50 | = | 110.0 | nM | 6.96 | Inhibition of ACAT2 (unknown origin) | - |
| Sterol O-acyltransferase 2 | IC50 | = | 110.0 | nM | 6.96 | Inhibition Assay: Methods for assessing the selectively of ACAT1 inhibitors are ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| 38569434 | 10.1016/j.ejmech.2024.116333 | Acetyl-CoA acetyltransferase, mitochondrial | 1 |
Data from ChEMBL 36 via Core Engine