Compound Detail
CHEMBL1914655
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Basic Information
| ChEMBL ID | CHEMBL1914655 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XESVKZYWJYQTNB-UTONKHPSSA-N |
| Parent Compound | CHEMBL1963388 |
| Active Moiety | CHEMBL1963388 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
409.3
MW (Da)
5.27
ALogP
4
HBA
3
HBD
73.8
PSA (Ų)
0.43
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.21 | 7.21 | 62.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 62.0 | nM | 7.21 | Inhibition of EGFR by Z-LYTE assay | 22018877 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22018877 | 10.1016/j.ejmech.2011.10.012 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine