Assay Detail
Binding
CHEMBL1920033
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Inhibition of EGFR by Z-LYTE assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.64 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL587723 | AEE-788 | 2.0 | 1 | 8.70 |
| CHEMBL105053 | — | — | 1 | 8.48 |
| CHEMBL1914461 | — | — | 1 | 8.48 |
| CHEMBL1914653 | — | — | 1 | 8.43 |
| CHEMBL1914654 | — | — | 1 | 8.42 |
| CHEMBL1914665 | — | — | 1 | 8.40 |
| CHEMBL1914667 | — | — | 1 | 8.33 |
| CHEMBL1914668 | — | — | 1 | 8.18 |
| CHEMBL1914658 | — | — | 1 | 8.10 |
| CHEMBL1914660 | — | — | 1 | 8.05 |
| CHEMBL1914670 | — | — | 1 | 7.92 |
| CHEMBL1914674 | — | — | 1 | 7.85 |
| CHEMBL1914659 | — | — | 1 | 7.77 |
| CHEMBL1914662 | — | — | 1 | 7.58 |
| CHEMBL1914672 | — | — | 1 | 7.57 |
| CHEMBL1914673 | — | — | 1 | 7.54 |
| CHEMBL1914671 | — | — | 1 | 7.48 |
| CHEMBL1914663 | — | — | 1 | 7.35 |
| CHEMBL1914664 | — | — | 1 | 7.28 |
| CHEMBL1914655 | — | — | 1 | 7.21 |
| CHEMBL1914669 | — | — | 1 | 7.20 |
| CHEMBL1914661 | — | — | 1 | 7.02 |
| CHEMBL1914656 | — | — | 1 | 6.35 |
| CHEMBL1914666 | — | — | 1 | 6.00 |
| CHEMBL1914657 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL587723 | AEE-788 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL105053 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1914461 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1914653 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1914654 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1914665 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1914667 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1914668 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1914658 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1914660 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1914670 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1914674 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1914659 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1914662 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1914672 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1914673 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1914671 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1914663 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1914664 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1914655 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1914669 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1914661 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1914656 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1914666 | — | IC50 | = | 1008.0 | nM | 6.00 |
| CHEMBL1914657 | — | IC50 | = | 4608.0 | nM | 5.34 |