Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1915865

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)cc(C)c1C(=O)Nc1cc(C2(C(=O)O)CC2)ccc1Cl

Basic Information

ChEMBL ID CHEMBL1915865
Phase Preclinical
Structure Type MOL
InChI Key GUWAOSSGBYSTNR-NRFANRHFSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

521.0
MW (Da)
5.60
ALogP
5
HBA
2
HBD
88.1
PSA (Ų)
0.42
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H29ClN2O5
MW 521.01
Aromatic Rings 3
Heavy Atoms 37
NP-Likeness -0.63

Activity Summary

IC50 2 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Prostaglandin D2 receptor
CHEMBL3933
IC50 9.0 9.0 1.0 1
Prostaglandin D2 receptor
CHEMBL4427
IC50 8.19 8.19 6.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21982795 10.1016/j.bmc.2011.08.065 Prostaglandin D2 receptor 2
21982795 10.1016/j.bmc.2011.08.065 Prostacyclin receptor 1
21982795 10.1016/j.bmc.2011.08.065 No relevant target 1

Data from ChEMBL 36 via Core Engine