Assay Detail
Functional
CHEMBL1918136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse prostanoid DP receptor expressed in CHO cells assessed as inhibition of PGD2-induced intracellular cAMP production after 10 mins by enzyme immunoassay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new orally active prostaglandin D2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.12 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915863 | — | — | 1 | 9.15 |
| CHEMBL1915865 | — | — | 1 | 9.00 |
| CHEMBL1915866 | — | — | 1 | 8.85 |
| CHEMBL1915858 | — | — | 1 | 8.82 |
| CHEMBL1819615 | — | — | 1 | 8.74 |
| CHEMBL364841 | — | — | 1 | 8.62 |
| CHEMBL1819608 | — | — | 1 | 8.48 |
| CHEMBL1915672 | — | — | 1 | 8.46 |
| CHEMBL1819622 | — | — | 1 | 8.37 |
| CHEMBL1915857 | — | — | 1 | 8.37 |
| CHEMBL1819611 | — | — | 1 | 8.34 |
| CHEMBL1915675 | — | — | 1 | 8.32 |
| CHEMBL1915677 | — | — | 1 | 8.29 |
| CHEMBL1915674 | — | — | 1 | 8.24 |
| CHEMBL1819619 | — | — | 1 | 8.22 |
| CHEMBL1915861 | — | — | 1 | 8.15 |
| CHEMBL1819623 | — | — | 1 | 8.13 |
| CHEMBL1915856 | — | — | 1 | 8.12 |
| CHEMBL1915673 | — | — | 1 | 7.92 |
| CHEMBL1915859 | — | — | 1 | 7.85 |
| CHEMBL1819609 | — | — | 1 | 7.70 |
| CHEMBL1915670 | — | — | 1 | 7.66 |
| CHEMBL1915867 | — | — | 1 | 7.62 |
| CHEMBL1915864 | — | — | 1 | 7.58 |
| CHEMBL1915860 | — | — | 1 | 7.57 |
| CHEMBL1915671 | — | — | 1 | 7.55 |
| CHEMBL1915862 | — | — | 1 | 7.37 |
| CHEMBL1915676 | — | — | 1 | 7.27 |
| CHEMBL1819603 | — | — | 1 | 6.66 |
| CHEMBL1915669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915863 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1915865 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1915866 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1915858 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1819615 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL364841 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1819608 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1915672 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1819622 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1915857 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1819611 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1915675 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1915677 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL1915674 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1819619 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1915861 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1819623 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL1915856 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1915673 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1915859 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1819609 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1915670 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1915867 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1915864 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1915860 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1915671 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1915862 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1915676 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1819603 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1915669 | — | IC50 | - | — | - | |
| CHEMBL1819614 | — | IC50 | - | — | - |