Compound Detail
CHEMBL1915867
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Cc1ccc2c(c1)[C@H](COc1cc(C)c(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(C)c1)CO2
Basic Information
| ChEMBL ID | CHEMBL1915867 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NXTVJLPVVYHNJC-LJQANCHMSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
480.0
MW (Da)
5.70
ALogP
4
HBA
2
HBD
84.9
PSA (Ų)
0.45
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin D2 receptor CHEMBL3933 | IC50 | 7.62 | 7.62 | 24.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin D2 receptor | IC50 | = | 24.0 | nM | 7.62 | Antagonist activity at mouse prostanoid DP receptor expressed in CHO cells asses... | 21982795 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21982795 | 10.1016/j.bmc.2011.08.065 | Prostacyclin receptor | 1 |
| 21982795 | 10.1016/j.bmc.2011.08.065 | Prostaglandin D2 receptor | 1 |
Data from ChEMBL 36 via Core Engine