Compound Detail
CHEMBL1951071
ARFORMOTEROL TARTRATE 💊 Approved Drug
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💊 Approved Drug
COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1.O=C(O)C(O)C(O)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL1951071 |
| Name | ARFORMOTEROL TARTRATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | FCSXYHUNDAXDRH-QVRIGTRMSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL1363 |
| Active Moiety | CHEMBL1363 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
3
Known Names
4
Indications
1
Mechanisms
Molecular Properties
344.4
MW (Da)
2.22
ALogP
5
HBA
4
HBD
90.8
PSA (Ų)
0.41
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2006 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Beta-2 adrenergic receptor agonist | AGONIST | Beta-2 adrenergic receptor | ✓ | ✓ |
Indications
Bronchitis, Chronic Emphysema Pulmonary Disease, Chronic Obstructive Bronchitis
Activity Summary
EC50 1 meas. best 9.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL5414 | EC50 | 9.9 | 9.9 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | EC50 | = | 0.1259 | nM | 9.9 | Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of h... | 22297114 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22297114 | 10.1016/j.bmcl.2012.01.013 | Beta-2 adrenergic receptor | 2 |
Data from ChEMBL 36 via Core Engine