Compound Detail
CHEMBL196003
PROMEGESTONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL196003 |
| Name | PROMEGESTONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | QFFCYTLOTYIJMR-XMGTWHOFSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
16
Publications
3
Known Names
Molecular Properties
326.5
MW (Da)
5.18
ALogP
2
HBA
0
HBD
34.1
PSA (Ų)
0.70
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
ATC Classification
G03DB07
promegestone
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Activity Summary
IC50 2 meas. best 9.63
Kd 1 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | IC50 | 9.63 | 9.63 | 0.2 | 1 |
| Progesterone receptor CHEMBL208 | Kd | 9.4 | 9.4 | 0.4 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 5.88 | 5.88 | 1318.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | IC50 | = | 0.236 | nM | 9.63 | Agonist activity at GAL4 DNA-binding domain fused PR (unknown origin) ligand bin... | 30144697 |
| Progesterone receptor | Kd | = | 0.4 | nM | 9.4 | Binding affinity to progesterone receptor | 20355713 |
| Androgen receptor | IC50 | = | 1318.26 | nM | 5.88 | Inhibitory concentration against recombinant rat androgen receptor expressed in ... | 16134935 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 2897467 | 10.1021/jm00401a015 | Glucocorticoid receptor | 7 |
| 7830275 | 10.1021/jm00002a014 | Progesterone receptor | 3 |
| 2897467 | 10.1021/jm00401a015 | Progesterone receptor | 1 |
| 2897467 | 10.1021/jm00401a015 | Androgen receptor | 1 |
| 2897467 | 10.1021/jm00401a015 | Mineralocorticoid receptor | 1 |
| 8487253 | 10.1021/jm00061a002 | Progesterone receptor | 1 |
| 8487253 | 10.1021/jm00061a002 | Mineralocorticoid receptor | 1 |
| 8487253 | 10.1021/jm00061a002 | Glucocorticoid receptor | 1 |
| 8487253 | 10.1021/jm00061a002 | No relevant target | 1 |
| 7830275 | 10.1021/jm00002a014 | No relevant target | 1 |
| 16134935 | 10.1021/jm050403f | Androgen receptor | 1 |
| 20355713 | 10.1021/jm100052k | Progesterone receptor | 1 |
| 926114 | 10.1021/jm00219a006 | Progesterone receptor | 1 |
| 30144697 | 10.1016/j.ejmech.2018.08.006 | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine