Compound Detail
CHEMBL197188
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Basic Information
| ChEMBL ID | CHEMBL197188 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YIFNILRPNDYIBP-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
314.4
MW (Da)
4.92
ALogP
2
HBA
2
HBD
40.5
PSA (Ų)
0.70
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.77
Ki 1 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Estrogen receptor beta CHEMBL242 | Ki | 8.89 | 8.89 | 1.3 | 1 |
| Estrogen receptor CHEMBL206 | EC50 | 7.77 | 7.77 | 17.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Estrogen receptor beta | Ki | = | 1.3 | nM | 8.89 | Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estra... | 16162002 |
| Estrogen receptor | EC50 | = | 17.0 | nM | 7.77 | Transcriptional activation of estrogen receptor alpha in U2OS cell using estroge... | 16162002 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16162002 | 10.1021/jm050226i | Estrogen receptor | 3 |
| 16162002 | 10.1021/jm050226i | Estrogen receptor beta | 2 |
Data from ChEMBL 36 via Core Engine