Compound Detail
CHEMBL2000619
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Basic Information
| ChEMBL ID | CHEMBL2000619 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UFNVWVLAJPJVLU-RWEWTDSWSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
395.5
MW (Da)
4.86
ALogP
4
HBA
1
HBD
56.1
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 CHEMBL1293302 | IC50 | 6.06 | 6.06 | 868.2 | 1 |
| Protein Rev CHEMBL1293282 | IC50 | 5.98 | 5.98 | 1047.0 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | IC50 | 4.97 | 4.97 | 10636.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 | IC50 | = | 868.25 | nM | 6.06 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Protein Rev | IC50 | = | 1047.0 | nM | 5.98 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarizati... | - |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | IC50 | = | 10636.06 | nM | 4.97 | PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibito... | - |
Data from ChEMBL 36 via Core Engine