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Compound Detail

CHEMBL2002323

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Cc1ccc(F)c(-c2ccc3nnc(N)n3c2)c1

Basic Information

ChEMBL ID CHEMBL2002323
Phase Preclinical
Structure Type MOL
InChI Key XLXFTYZLDQSWSY-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

242.3
MW (Da)
2.43
ALogP
4
HBA
1
HBD
56.2
PSA (Ų)
0.71
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H11FN4
MW 242.26
Aromatic Rings 3
Heavy Atoms 18
NP-Likeness -1.81

Activity Summary

Ki 3 meas. best 7.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Proto-oncogene tyrosine-protein kinase Src
CHEMBL267
Ki 7.8 7.8 15.8 1
Serine/threonine-protein kinase pim-1
CHEMBL2147
Ki 5.6 5.6 2511.9 1
Glycogen synthase kinase-3 alpha
CHEMBL2850
Ki 5.4 5.4 3981.1 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine