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Compound Detail

CHEMBL200636

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c1ccc2nc(-c3nc4ccccc4[nH]3)cnc2c1

Basic Information

ChEMBL ID CHEMBL200636
Phase Preclinical
Structure Type MOL
InChI Key AYFBMQMYJRNGIM-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

246.3
MW (Da)
3.17
ALogP
3
HBA
1
HBD
54.5
PSA (Ų)
0.56
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H10N4
MW 246.27
Aromatic Rings 4
Heavy Atoms 19
NP-Likeness -1.12

Activity Summary

Ki 6 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL226
Ki 7.3 7.3 50.0 2
Adenosine receptor A2a
CHEMBL251
Ki 6.25 6.25 561.0 2
Adenosine receptor A3
CHEMBL256
Ki 6.12 6.12 763.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16366607 10.1021/jm050792d Adenosine receptor A1 1
16366607 10.1021/jm050792d Adenosine receptor A2a 1
16366607 10.1021/jm050792d Adenosine receptor A3 1
18269230 10.1021/jm701159t Adenosine receptor A1 1
18269230 10.1021/jm701159t Adenosine receptor A3 1
18269230 10.1021/jm701159t Adenosine receptor A2a 1

Data from ChEMBL 36 via Core Engine