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Compound Detail

CHEMBL2012520

LY377604
🧪 Phase II
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🧪 Phase II
CC(C)(Cc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NC[C@H](O)COc1cccc2[nH]c3ccccc3c12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2012520
Name LY377604
Phase Phase II
Structure Type MOL
InChI Key RBSGUQYXRDKPAE-QFIPXVFZSA-N

Known Names

Ly-377604 Ly377604
0
Targets
0
Activities
0
Assay Types
2
PK Parameters
2
Publications
2
Known Names
1
Indications
3
Mechanisms

Molecular Properties

524.6
MW (Da)
4.96
ALogP
6
HBA
4
HBD
122.5
PSA (Ų)
0.19
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product

Extended Properties

Molecular Formula C31H32N4O4
MW 524.62
Aromatic Rings 5
Heavy Atoms 39
NP-Likeness -0.65

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Beta-3 adrenergic receptor agonist AGONIST Beta-3 adrenergic receptor ✓ ✓
Beta-2 adrenergic receptor antagonist ANTAGONIST Beta-2 adrenergic receptor ✓ ✓
Beta-1 adrenergic receptor antagonist ANTAGONIST Beta-1 adrenergic receptor ✓ ✓

Indications

Obesity

Pharmacokinetic Data

Parameter Value Units Species
T1/2 9.0 hr Homo sapiens
Tmax 2.0 hr Homo sapiens

Literature References

PubMed DOI Target Context # Activities
24900353 10.1021/ml200071k Homo sapiens 5
24900353 10.1021/ml200071k Rattus norvegicus 4

Data from ChEMBL 36 via Core Engine