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Compound Detail

CHEMBL2012680

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CCNc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@@H]2C[C@@H]21

Basic Information

ChEMBL ID CHEMBL2012680
Phase Preclinical
Structure Type MOL
InChI Key AQEVNHBIMHWEKH-LUTUWXHWSA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

309.8
MW (Da)
0.82
ALogP
7
HBA
3
HBD
96.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H16ClN5O2
MW 309.76
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness 0.05

Activity Summary

Ki 6 meas. best 8.18

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 8.18 7.5267 6.6 3
Adenosine receptor A1
CHEMBL226
Ki 6.03 6.03 930.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22921089 10.1021/jm300965a Adenosine receptor A1 2
21858244 10.1021/ml200114q Adenosine receptor A3 1
21858244 10.1021/ml200114q Adenosine receptor A2a 1
21858244 10.1021/ml200114q Adenosine receptor A1 1
22921089 10.1021/jm300965a Adenosine receptor A3 1
22921089 10.1021/jm300965a Adenosine receptor A2a 1
30568760 10.1039/C8MD00317C Adenosine receptor A3 1
30568760 10.1039/C8MD00317C Adenosine receptor A2a 1
30568760 10.1039/C8MD00317C Adenosine receptor A1 1

Data from ChEMBL 36 via Core Engine