Compound Detail
CHEMBL2022653
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Cn1c(SCC(=O)[C@@]2(O)CC[C@H]3[C@@H]4CCC5=Cc6c(cnn6-c6ccccc6)C[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)nc2ccccc21
Basic Information
| ChEMBL ID | CHEMBL2022653 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GDPBRHOXHFXBSK-BVNXUOMESA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
608.8
MW (Da)
6.00
ALogP
8
HBA
2
HBD
93.2
PSA (Ų)
0.27
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 8.33 | 7.7433 | 4.7 | 3 |
| Glucocorticoid receptor CHEMBL3368 | IC50 | 7.11 | 7.11 | 78.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | IC50 | = | 4.7 | nM | 8.33 | Transrepression activity at glucocorticoid receptor in human H292 cells assessed... | 22465636 |
| Glucocorticoid receptor | IC50 | = | 19.1 | nM | 7.72 | Transactivation activity at human glucocorticoid receptor in cells co-expressing... | 22465636 |
| Glucocorticoid receptor | IC50 | = | 66.7 | nM | 7.18 | Transactivation activity at glucocorticoid receptor in human HepG2 cells assesse... | 22465636 |
| Glucocorticoid receptor | IC50 | = | 78.0 | nM | 7.11 | Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed... | 22465636 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22465636 | 10.1016/j.bmcl.2012.03.015 | Glucocorticoid receptor | 8 |
Data from ChEMBL 36 via Core Engine