Compound Detail
CHEMBL2029020
MOENOMYCIN Enter ChEMBL ID:
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C=C(C/C=C(\C)CCC=C(C)C)CCC(C)(C)/C=C/CC/C(C)=C\CO[C@H](COP(=O)(O)O[C@H]1O[C@@H](C(N)=O)[C@@](C)(O)[C@H](OC(N)=O)[C@@H]1O[C@@H]1O[C@@H](CO[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@@H]3O[C@@H](C(=O)NC4=C(O)CCC4=O)[C@H](O)[C@H](O)[C@@H]3O)[C@H](O)[C@@H]2NC(C)=O)[C@@H](O)[C@@H]1NC(C)=O)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL2029020 |
| Name | MOENOMYCIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CWWXIJNUPCBGQG-WJIPNRKMSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
1582.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Escherichia coli CHEMBL354 | IC50 | 7.81 | 7.66 | 15.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Escherichia coli | IC50 | = | 15.6 | nM | 7.81 | Compound was evaluated for inhibition of peptidoglycan synthesis in Escherichia ... | 11055331 |
| Escherichia coli | IC50 | = | 31.0 | nM | 7.51 | Compound was evaluated for inhibition of peptidoglycan synthesis in Escherichia ... | 11055331 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Enterococcus faecalis | 5 |
| 10464005 | 10.1021/jm990212a | Enterococcus faecalis | 4 |
| 10464005 | 10.1021/jm990212a | Enterococcus faecium | 3 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Escherichia coli | 3 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Enterococcus faecium | 3 |
| 10464005 | 10.1021/jm990212a | Staphylococcus aureus | 2 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Staphylococcus aureus | 2 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Staphylococcus epidermidis | 2 |
| 10464005 | 10.1021/jm990212a | Unchecked | 1 |
| 10464005 | 10.1021/jm990212a | Staphylococcus epidermidis | 1 |
| 10464005 | 10.1021/jm990212a | Escherichia coli | 1 |
Data from ChEMBL 36 via Core Engine