Assay Detail
Functional
CHEMBL674553
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Compound was evaluated for inhibition of peptidoglycan synthesis in Escherichia coli using [14C]-lipid II radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Differential antibacterial activity of moenomycin analogues on gram-positive bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.35 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2029020 | MOENOMYCIN | — | 1 | 7.51 |
| CHEMBL2029021 | — | — | 1 | 7.06 |
| CHEMBL2029019 | — | — | 1 | 7.01 |
| CHEMBL406969 | — | — | 1 | 6.88 |
| CHEMBL72658 | — | — | 1 | 6.62 |
| CHEMBL262777 | VANCOMYCIN | 4.0 | 1 | 5.35 |
| CHEMBL279571 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2029020 | MOENOMYCIN | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2029021 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL2029019 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL406969 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL72658 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL262777 | VANCOMYCIN | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL279571 | — | IC50 | = | 100000.0 | nM | 4.00 |