Compound Detail
CHEMBL279571
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CCCCCCCCCCCCO[C@H](COP(=O)(O)OC1OC(C(N)=O)C(O)C(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)C1OC1OC(CO)C(O)C(O)C1NC(=O)c1cccc(C(F)(F)F)c1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL279571 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OXNRTOOUNKRGSZ-IRTOLXGVSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
1083.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Enterococcus faecalis CHEMBL362 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| Escherichia coli CHEMBL354 | IC50 | 5.01 | 4.505 | 9800.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Enterococcus faecalis | IC50 | = | 2500.0 | nM | 5.6 | Compound was evaluated for inhibition of peptidoglycan synthesis in Enterococcus... | 11055331 |
| Escherichia coli | IC50 | = | 9800.0 | nM | 5.01 | Compound was evaluated for inhibition of peptidoglycan synthesis in Escherichia ... | 11055331 |
| Escherichia coli | IC50 | = | 100000.0 | nM | 4.0 | Compound was evaluated for inhibition of peptidoglycan synthesis in Escherichia ... | 11055331 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Enterococcus faecalis | 5 |
| 10464005 | 10.1021/jm990212a | Enterococcus faecalis | 4 |
| 10464005 | 10.1021/jm990212a | Enterococcus faecium | 3 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Escherichia coli | 3 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Enterococcus faecium | 3 |
| 10464005 | 10.1021/jm990212a | Staphylococcus aureus | 2 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Staphylococcus aureus | 2 |
| 11055331 | 10.1016/s0960-894x(00)00443-1 | Staphylococcus epidermidis | 2 |
| 10464005 | 10.1021/jm990212a | Unchecked | 1 |
| 10464005 | 10.1021/jm990212a | Staphylococcus epidermidis | 1 |
| 10464005 | 10.1021/jm990212a | Escherichia coli | 1 |
Data from ChEMBL 36 via Core Engine