Assay Detail
Functional
CHEMBL677328
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Compound was evaluated for inhibition of peptidoglycan synthesis in Enterococcus faecalis using [14C]lysine radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterococcus faecalis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Differential antibacterial activity of moenomycin analogues on gram-positive bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.16 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279571 | — | — | 1 | 5.60 |
| CHEMBL262777 | VANCOMYCIN | 4.0 | 1 | 5.58 |
| CHEMBL406969 | — | — | 1 | 4.30 |
| CHEMBL2029021 | — | — | 1 | - |
| CHEMBL2029020 | MOENOMYCIN | — | 1 | - |
| CHEMBL2029019 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279571 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL262777 | VANCOMYCIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL406969 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL2029021 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL2029020 | MOENOMYCIN | IC50 | > | 700000.0 | nM | - |
| CHEMBL2029019 | — | IC50 | > | 700000.0 | nM | - |