Assay Detail
Functional
CHEMBL674552
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Compound was evaluated for inhibition of peptidoglycan synthesis in Escherichia coli using UDP-[14C]-GlcNAc radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Differential antibacterial activity of moenomycin analogues on gram-positive bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.10 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2029019 | — | — | 1 | 8.09 |
| CHEMBL2029021 | — | — | 1 | 8.07 |
| CHEMBL2029020 | MOENOMYCIN | — | 1 | 7.81 |
| CHEMBL406969 | — | — | 1 | 7.80 |
| CHEMBL72658 | — | — | 1 | 7.48 |
| CHEMBL262777 | VANCOMYCIN | 4.0 | 1 | 5.43 |
| CHEMBL279571 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2029019 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL2029021 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL2029020 | MOENOMYCIN | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL406969 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL72658 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL262777 | VANCOMYCIN | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL279571 | — | IC50 | = | 9800.0 | nM | 5.01 |