Compound Detail

CHEMBL2051970

PIVOPRIL

🧪 Phase II

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🧪 Phase II

C[C@H](CSC(=O)C(C)(C)C)C(=O)N(CC(=O)O)C1CCCC1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2051970
Name	PIVOPRIL
Phase	Phase II
Structure Type	MOL
InChI Key	XRKXJJYSKUIIEN-LLVKDONJSA-N

Pivopril REV 3569-(S) REV 3659-(S) REV-3659 (S) REV-3659-(S) RHC 3659-(S) RHC-3659 (S) RHC-3659-(S) USV 3659-(S) USV-3659 (S) USV-3659-(S)

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

329.5

MW (Da)

2.78

ALogP

HBA

HBD

74.7

PSA (Å²)

0.81

QED

Ro5 Violations

Rot. Bonds

Molecule Type	Small molecule
Chirality	Single Enantiomer

USAN Stem	-pril
USAN Year	1985

IC50 3 meas. best 7.77

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Angiotensin-converting enzyme CHEMBL4074	IC50	7.77	6.2167	17.0	3

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Angiotensin-converting enzyme	IC50	=	17.0	nM	7.77	In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rab...	3009814
Angiotensin-converting enzyme	IC50	=	3600.0	nM	5.44	In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung	3009814
Angiotensin-converting enzyme	IC50	=	3600.0	nM	5.44	In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme...	2981324

PubMed	DOI	Target Context	# Activities
3009814	10.1021/jm00155a032	Angiotensin-converting enzyme	2
3009814	10.1021/jm00155a032	Angiotensin II receptor (AT-1) type-1	2
3009814	10.1021/jm00155a032	Rattus norvegicus	2
2981324	10.1021/jm00379a013	Angiotensin-converting enzyme	2
2981324	10.1021/jm00379a013	Canis familiaris	1

Data from ChEMBL 36 via Core Engine