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Compound Detail

CHEMBL2052004

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COCc1c[nH]c(-c2ccc(OC[C@@H](O)CNCCc3ccc(OC)c(OC)c3)cc2)n1

Basic Information

ChEMBL ID CHEMBL2052004
Phase Preclinical
Structure Type MOL
InChI Key VCZOJHDSELRWFA-FQEVSTJZSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

441.5
MW (Da)
2.81
ALogP
7
HBA
3
HBD
97.9
PSA (Ų)
0.35
QED
0
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H31N3O5
MW 441.53
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.58

Activity Summary

Kd 2 meas. best 7.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 7.77 7.77 17.0 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 4.42 4.42 38018.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2872332 10.1021/jm00156a028 Beta-1 adrenergic receptor 1
2872332 10.1021/jm00156a028 Beta-2 adrenergic receptor 1
2872332 10.1021/jm00156a028 Adrenergic receptor beta; ADRB1 & ADRB2 1

Data from ChEMBL 36 via Core Engine