Compound Detail
CHEMBL206798
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Basic Information
| ChEMBL ID | CHEMBL206798 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHZRIUCQCGDOGQ-IBGZPJMESA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
3.15
ALogP
3
HBA
2
HBD
64.0
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.4
EC50 1 meas. best 8.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kinesin-like protein KIF11 CHEMBL4581 | IC50 | 8.4 | 8.4 | 4.0 | 2 |
| A2780 CHEMBL614004 | EC50 | 8.04 | 8.04 | 9.1 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kinesin-like protein KIF11 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of KSP by ATPase assay | 16439122 |
| Kinesin-like protein KIF11 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of KSP | 17095225 |
| A2780 | EC50 | = | 9.1 | nM | 8.04 | Mitotic arrest in A2780 cells | 16439122 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 15000.0 | nM | 4.82 | Inhibitory activity against human hERG receptor expressed in HEK cells | 16439122 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16439122 | 10.1016/j.bmcl.2005.12.094 | Kinesin-like protein KIF11 | 1 |
| 16439122 | 10.1016/j.bmcl.2005.12.094 | A2780 | 1 |
| 16439122 | 10.1016/j.bmcl.2005.12.094 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 17095225 | 10.1016/j.bmcl.2006.10.083 | Kinesin-like protein KIF11 | 1 |
Data from ChEMBL 36 via Core Engine