Assay Detail
Functional
CHEMBL868958
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Mitotic arrest in A2780 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.16 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262736 | — | — | 1 | 8.59 |
| CHEMBL206115 | — | — | 1 | 8.52 |
| CHEMBL377596 | — | — | 1 | 8.51 |
| CHEMBL381526 | — | — | 1 | 8.48 |
| CHEMBL206249 | — | — | 1 | 8.07 |
| CHEMBL206798 | — | — | 1 | 8.04 |
| CHEMBL381533 | — | — | 1 | 7.66 |
| CHEMBL378547 | — | — | 1 | 7.43 |
| CHEMBL439342 | — | — | 1 | - |
| CHEMBL382994 | — | — | 1 | - |
| CHEMBL202734 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262736 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL206115 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL377596 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL381526 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL206249 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL206798 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL381533 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL378547 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL439342 | — | EC50 | - | — | - | |
| CHEMBL382994 | — | EC50 | - | — | - | |
| CHEMBL202734 | — | EC50 | - | — | - |