Compound Detail
CHEMBL2069631
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Basic Information
| ChEMBL ID | CHEMBL2069631 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QDEOKQNSXNQTMN-XJKSGUPXSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
289.4
MW (Da)
2.61
ALogP
3
HBA
1
HBD
55.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase CHEMBL4349 | IC50 | 6.5 | 6.5 | 314.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase | IC50 | = | 314.0 | nM | 6.5 | Inhibition of human recombinant His6-tagged NAAA expressed in HEK293 cells using... | 24900487 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900487 | 10.1021/ml300056y | N-acylethanolamine-hydrolyzing acid amidase | 2 |
Data from ChEMBL 36 via Core Engine