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Compound Detail

CHEMBL207222

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CC(C)(S)[C@H](N)C(=O)O

Basic Information

ChEMBL ID CHEMBL207222
Phase Preclinical
Structure Type MOL
InChI Key VVNCNSJFMMFHPL-GSVOUGTGSA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

149.2
MW (Da)
0.11
ALogP
3
HBA
3
HBD
63.3
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C5H11NO2S
MW 149.22
Aromatic Rings 0
Heavy Atoms 9
NP-Likeness 1.17

Activity Summary

IC50 2 meas. best 5.28
Ki 1 meas. best 5.34

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Succinyl-diaminopimelate desuccinylase
CHEMBL1075192
Ki 5.34 5.34 4600.0 1
No relevant target
CHEMBL2362975
IC50 5.28 5.28 5200.0 1
Succinyl-diaminopimelate desuccinylase
CHEMBL1075192
IC50 4.86 4.86 13700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C2MD20020A Serine palmitoyltransferase 6
19822427 10.1016/j.bmcl.2009.09.077 Succinyl-diaminopimelate desuccinylase 2
23062825 10.1016/j.bmc.2012.09.040 Acetylcholinesterase 1
23062825 10.1016/j.bmc.2012.09.040 Cholinesterase 1
25677658 10.1016/j.bmcl.2015.01.054 No relevant target 1
38318365 10.1016/j.isci.2024.108907 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1

Data from ChEMBL 36 via Core Engine