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Target Snapshot

CHEMBL1075192 Target Snapshot

Succinyl-diaminopimelate desuccinylase · SINGLE PROTEIN · Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

33Compounds
15Assays
3Approved Drugs
30.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P44514. Use UniProt P44514 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P44514 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Succinyl-diaminopimelate desuccinylase as ChEMBL target CHEMBL1075192, mapped to UniProt P44514. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Succinyl-diaminopimelate desuccinylase
SINGLE PROTEIN · Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
As of 2026-09-14
ChEMBL target ID
CHEMBL1075192
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P44514
Succinyl-diaminopimelate desuccinylase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Succinyl-diaminopimelate desuccinylase is the right protein anchor across sources, using UniProt P44514 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSuccinyl-diaminopimelate desuccinylase
UniProt AccessionP44514
Component TypeProtein
Sequence Length377 aa

Succinyl-diaminopimelate desuccinylase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Succinyl-diaminopimelate desuccinylase, mapped to UniProt P44514. Sequence length is 377 aa.

Mapped IDP44514
Review nameSuccinyl-diaminopimelate desuccinylase
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5023.0
KI5.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5425782 6.05 IC50 890.0 Preclinical
CHEMBL1560 5.74 Ki 1820.0 Approved
CHEMBL1560 5.48 IC50 3300.0 Approved
CHEMBL207222 5.34 Ki 4600.0 Preclinical
CHEMBL207222 4.86 IC50 13700.0 Preclinical
CHEMBL291888 4.47 IC50 34000.0 Preclinical
CHEMBL434965 4.38 IC50 42000.0 Preclinical
CHEMBL1076479 4.37 IC50 43000.0 Preclinical
CHEMBL1430 4.3 IC50 50000.0 Approved
CHEMBL5290013 4.3 IC50 50200.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
2
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

15
Total Assays
15
Tested Compounds
1
Assay Types
Binding — 15 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 15 15 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine