Assay Detail
Binding
CHEMBL1101552
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Inhibition of Haemophilus influenzae recombinant DapE
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Haemophilus influenzae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Succinyl-diaminopimelate desuccinylase (CHEMBL1075192) ↗| Type | SINGLE PROTEIN |
| Organism | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Publication
Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.56 | 5.48 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 5.48 |
| CHEMBL207222 | — | — | 1 | 4.86 |
| CHEMBL291888 | — | — | 1 | 4.47 |
| CHEMBL434965 | D-CAPTOPRIL | — | 1 | 4.38 |
| CHEMBL1076479 | — | — | 1 | 4.37 |
| CHEMBL1430 | PENICILLAMINE | 4.0 | 1 | 4.30 |
| CHEMBL141272 | — | — | 1 | 4.04 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
| CHEMBL82324 | — | — | 1 | - |
| CHEMBL421765 | — | — | 1 | - |
| CHEMBL31962 | BUTYL BORONIC ACID | — | 1 | - |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | - |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | - |
| CHEMBL1086896 | — | — | 1 | - |
| CHEMBL263376 | PHENYLTHIOUREA | — | 1 | - |
| CHEMBL1088324 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL207222 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL291888 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL434965 | D-CAPTOPRIL | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1076479 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1430 | PENICILLAMINE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL141272 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL21485 | PHENYLBORONIC ACID | IC50 | = | 107000.0 | nM | - |
| CHEMBL82324 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL421765 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL31962 | BUTYL BORONIC ACID | IC50 | ~ | 10000000.0 | nM | - |
| CHEMBL578 | ENALAPRIL | IC50 | > | 1000000.0 | nM | - |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1086896 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL263376 | PHENYLTHIOUREA | IC50 | > | 100000.0 | nM | - |
| CHEMBL1088324 | — | IC50 | = | 1620000.0 | nM | - |
| CHEMBL1088324 | — | Ki | = | 800000.0 | nM | - |