Compound Detail
CHEMBL208457
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Basic Information
| ChEMBL ID | CHEMBL208457 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SWZSFUMMCHKHMM-OKWWDJPNSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
290.4
MW (Da)
5.05
ALogP
2
HBA
2
HBD
24.1
PSA (Ų)
0.73
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 8.12 | 7.515 | 7.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 7.5 | nM | 8.12 | Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine fr... | 16640346 |
| Amyloid-beta precursor protein | Ki | = | 122.0 | nM | 6.91 | Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbe... | 16640346 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16640346 | 10.1021/jm051020k | Amyloid-beta precursor protein | 2 |
Data from ChEMBL 36 via Core Engine