Assay Detail
Binding
CHEMBL865747
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Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of biphenyltrienes as probes for beta-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.71 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381642 | — | — | 1 | 8.92 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 8.55 |
| CHEMBL78012 | — | — | 1 | 8.30 |
| CHEMBL208457 | — | — | 1 | 8.12 |
| CHEMBL208456 | — | — | 1 | 8.05 |
| CHEMBL381731 | — | — | 1 | 8.05 |
| CHEMBL205332 | — | — | 1 | 7.92 |
| CHEMBL207649 | — | — | 1 | 6.82 |
| CHEMBL205899 | — | — | 1 | 6.30 |
| CHEMBL377929 | — | — | 1 | 6.08 |
| CHEMBL379363 | — | — | 1 | - |
| CHEMBL292910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381642 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL78012 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL208457 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL208456 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL381731 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL205332 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL207649 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL205899 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL377929 | — | Ki | = | 837.0 | nM | 6.08 |
| CHEMBL379363 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL292910 | — | Ki | > | 1000.0 | nM | - |