Compound Detail
CHEMBL2105269
METIAZINIC ACID 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2105269 |
| Name | METIAZINIC ACID |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | LMINNBXUMGNKMM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
5
Known Names
Molecular Properties
271.3
MW (Da)
3.55
ALogP
3
HBA
1
HBD
40.5
PSA (Ų)
0.91
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 2 meas. best 5.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 CHEMBL2949 | IC50 | 5.21 | 5.21 | 6230.0 | 1 |
| Prostaglandin G/H synthase 2 CHEMBL4102 | IC50 | 4.98 | 4.98 | 10450.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | IC50 | = | 6230.0 | nM | 5.21 | Inhibition of ovine COX1 assessed as reduction in PGH2 production by enzyme immu... | 29980364 |
| Prostaglandin G/H synthase 2 | IC50 | = | 10450.0 | nM | 4.98 | Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immu... | 29980364 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 29980364 | 10.1016/j.bmc.2018.06.038 | Unchecked | 1 |
| 29980364 | 10.1016/j.bmc.2018.06.038 | Prostaglandin G/H synthase 2 | 1 |
| 29980364 | 10.1016/j.bmc.2018.06.038 | Prostaglandin G/H synthase 1 | 1 |
Data from ChEMBL 36 via Core Engine