Assay Detail
ADMET
CHEMBL4233558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX1 assessed as reduction in PGH2 production by enzyme immunoassay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological properties of aryl methyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.89 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4241735 | — | — | 1 | 7.40 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | 6.96 |
| CHEMBL1240537 | — | — | 1 | 6.75 |
| CHEMBL4247064 | — | — | 1 | 6.41 |
| CHEMBL4248484 | — | — | 1 | 5.87 |
| CHEMBL1297 | FENOPROFEN | 4.0 | 1 | 5.56 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.47 |
| CHEMBL4238821 | — | — | 1 | 5.31 |
| CHEMBL4243293 | — | — | 1 | 5.28 |
| CHEMBL2105269 | METIAZINIC ACID | 2.0 | 1 | 5.21 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.15 |
| CHEMBL4242712 | — | — | 1 | 5.15 |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4241735 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL571 | KETOPROFEN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1240537 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4247064 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4248484 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL1297 | FENOPROFEN | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL4238821 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL4243293 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL2105269 | METIAZINIC ACID | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4242712 | — | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL154 | NAPROXEN | IC50 | = | 11300.0 | nM | 4.95 |