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Compound Detail

CHEMBL2112385

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C[C@@H](NC(=O)OC(C)(C)C)C(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12

Basic Information

ChEMBL ID CHEMBL2112385
Phase Preclinical
Structure Type MOL
InChI Key DRUWRKDQVHKKLD-LLVKDONJSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

456.9
MW (Da)
4.04
ALogP
8
HBA
2
HBD
123.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H21ClN6O4
MW 456.89
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.83

Activity Summary

Ki 3 meas. best 7.73

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
Ki 7.73 7.73 18.8 1
Adenosine receptor A3
CHEMBL256
Ki 7.33 7.33 46.3 1
Adenosine receptor A1
CHEMBL318
Ki 7.31 7.31 48.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9667972 10.1021/jm980094b Unchecked 2
9667972 10.1021/jm980094b Adenosine receptor A1 1
9667972 10.1021/jm980094b Adenosine receptor A2a 1
9667972 10.1021/jm980094b Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine