Compound Detail
CHEMBL212766
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CC(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N
Basic Information
| ChEMBL ID | CHEMBL212766 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WIUGVXOSBXINHH-UPRLRBBYSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
515.7
MW (Da)
3.13
ALogP
4
HBA
3
HBD
123.0
PSA (Ų)
0.21
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.63
Ki 3 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL259 | Ki | 7.05 | 7.05 | 90.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | EC50 | 6.63 | 6.63 | 232.0 | 1 |
| Melanocortin receptor 3 CHEMBL4644 | Ki | 6.54 | 6.54 | 289.0 | 1 |
| Melanocortin receptor 4 CHEMBL259 | EC50 | 6.5 | 6.5 | 317.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | Ki | 6.33 | 6.33 | 463.0 | 1 |
| Melanocortin receptor 3 CHEMBL4644 | EC50 | 5.86 | 5.86 | 1384.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 4 | Ki | = | 90.0 | nM | 7.05 | Displacement of europium labeled NDP-alpha-MSH from human MC4R expressed in HEK2... | 16854081 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 232.0 | nM | 6.63 | Agonist activity at human MC1R transfected in HEK293 cells | 16854081 |
| Melanocortin receptor 3 | Ki | = | 289.0 | nM | 6.54 | Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK2... | 16854081 |
| Melanocortin receptor 4 | EC50 | = | 317.0 | nM | 6.5 | Agonist activity at human MC4R transfected in HEK293 cells | 16854081 |
| Melanocyte-stimulating hormone receptor | Ki | = | 463.0 | nM | 6.33 | Displacement of europium labeled NDP-alpha-MSH from human MC1R expressed in HEK2... | 16854081 |
| Melanocortin receptor 3 | EC50 | = | 1384.0 | nM | 5.86 | Agonist activity at human MC3R transfected in HEK293 cells | 16854081 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16854081 | 10.1021/jm060384p | Melanocortin receptor 4 | 3 |
| 16854081 | 10.1021/jm060384p | Melanocortin receptor 3 | 3 |
| 16854081 | 10.1021/jm060384p | Melanocyte-stimulating hormone receptor | 3 |
| 16854081 | 10.1021/jm060384p | Caco-2 | 2 |
Data from ChEMBL 36 via Core Engine