Compound Detail
CHEMBL212827
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Basic Information
| ChEMBL ID | CHEMBL212827 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WNZAIUIEXCYTCY-UHFFFAOYSA-N |
2
Targets
6
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
215.2
MW (Da)
2.79
ALogP
2
HBA
1
HBD
42.2
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 4.86
IC50 2 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.86 | 4.86 | 13945.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.69 | 4.69 | 20528.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RNA-binding protein pos-1 | EC50 | = | 13945.0 | nM | 4.86 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Zinc finger protein mex-5 | EC50 | = | 20528.0 | nM | 4.69 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19053778 | 10.1021/jm800869t | Unchecked | 2 |
| 16913712 | 10.1021/jm0605132 | Lethal factor | 1 |
| 18226912 | 10.1016/j.bmc.2007.12.034 | Unchecked | 1 |
| 19053778 | 10.1021/jm800869t | Human immunodeficiency virus 1 | 1 |
| 19053778 | 10.1021/jm800869t | MT2 | 1 |
| 26154240 | 10.1016/j.bmc.2015.06.042 | Curvularia lunata | 1 |
| 28082071 | 10.1016/j.bmc.2016.12.049 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine