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Compound Detail

CHEMBL214662

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C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)C[C@@H]4OC(=O)C(=C)[C@@H]4C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O

Basic Information

ChEMBL ID CHEMBL214662
Phase Preclinical
Structure Type MOL
InChI Key RBARJWNZIPXVBN-AVCGANDTSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

440.6
MW (Da)
5.27
ALogP
4
HBA
2
HBD
66.8
PSA (Ų)
0.46
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H40O4
MW 440.62
Aromatic Rings 0
Heavy Atoms 32
NP-Likeness 2.74

Activity Summary

IC50 1 meas. best 8.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vitamin D3 receptor
CHEMBL1977
IC50 8.11 8.11 7.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17125259 10.1021/jm060797q Vitamin D3 receptor 3

Data from ChEMBL 36 via Core Engine