Assay Detail
Functional
CHEMBL910037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against 1-alpha,25-dihydroxy vitamin D3-induced HL60 cell differentiation by NBT reduction method
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 84 | 8.12 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383910 | — | — | 1 | 8.22 |
| CHEMBL216037 | — | — | 1 | 8.22 |
| CHEMBL386412 | — | — | 1 | 8.22 |
| CHEMBL213868 | — | — | 1 | 8.22 |
| CHEMBL387098 | — | — | 1 | 8.22 |
| CHEMBL384614 | — | — | 1 | 8.22 |
| CHEMBL383850 | — | — | 1 | 8.22 |
| CHEMBL217385 | — | — | 1 | 8.21 |
| CHEMBL387220 | — | — | 1 | 8.21 |
| CHEMBL385205 | — | — | 1 | 8.21 |
| CHEMBL385705 | — | — | 1 | 8.21 |
| CHEMBL217924 | — | — | 1 | 8.21 |
| CHEMBL215164 | — | — | 1 | 8.21 |
| CHEMBL385707 | — | — | 1 | 8.21 |
| CHEMBL214978 | — | — | 1 | 8.21 |
| CHEMBL215239 | — | — | 1 | 8.20 |
| CHEMBL215360 | — | — | 1 | 8.20 |
| CHEMBL387281 | — | — | 1 | 8.20 |
| CHEMBL385342 | — | — | 1 | 8.20 |
| CHEMBL214500 | — | — | 1 | 8.20 |
| CHEMBL217417 | — | — | 1 | 8.20 |
| CHEMBL384370 | — | — | 1 | 8.20 |
| CHEMBL218565 | — | — | 1 | 8.20 |
| CHEMBL217447 | — | — | 1 | 8.20 |
| CHEMBL215306 | — | — | 1 | 8.20 |
| CHEMBL383902 | — | — | 1 | 8.20 |
| CHEMBL384929 | — | — | 1 | 8.20 |
| CHEMBL385926 | — | — | 1 | 8.20 |
| CHEMBL384020 | — | — | 1 | 8.17 |
| CHEMBL217030 | — | — | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383910 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL216037 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL386412 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL213868 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL387098 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL384614 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL383850 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL217924 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL387220 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL385205 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL385705 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL217385 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL215164 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL385707 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL214978 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL385342 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL215360 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL387281 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL214500 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL217417 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL384370 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL217447 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL215306 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL383902 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL384929 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL385926 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL215239 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL218565 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL217335 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL386623 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL215968 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL215518 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL215806 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL215173 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL214469 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL217030 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL384020 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL384538 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL214662 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL410320 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL217265 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL213915 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL387286 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL214135 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL214786 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL383856 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL385830 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL214134 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL218183 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL385871 | — | IC50 | = | 8.4 | nM | 8.08 |