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Compound Detail

CHEMBL383902

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C=C1C[C@H](C[C@@H](C)[C@H]2CC[C@H]3/C(=C/C=C4/C[C@@H](O)C[C@H](O)C4=C)CCC[C@]23C)OC1=O

Basic Information

ChEMBL ID CHEMBL383902
Phase Preclinical
Structure Type MOL
InChI Key SAODSJHDCZTVAT-CZADFQNYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

426.6
MW (Da)
5.03
ALogP
4
HBA
2
HBD
66.8
PSA (Ų)
0.49
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H38O4
MW 426.60
Aromatic Rings 0
Heavy Atoms 31
NP-Likeness 2.90

Activity Summary

IC50 1 meas. best 8.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vitamin D3 receptor
CHEMBL1977
IC50 8.2 8.2 6.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16480267 10.1021/jm050795q Vitamin D3 receptor 3
17125259 10.1021/jm060797q Vitamin D3 receptor 2

Data from ChEMBL 36 via Core Engine