Compound Detail
CHEMBL2164598
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Basic Information
| ChEMBL ID | CHEMBL2164598 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OMBKKJNDLJGHQA-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
401.5
MW (Da)
5.14
ALogP
3
HBA
1
HBD
44.8
PSA (Ų)
0.64
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 7.96 | 7.82 | 11.0 | 3 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 6.19 | 6.19 | 640.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 11.0 | nM | 7.96 | Inhibition of human FAAH after 1 hr | 24900385 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 18.0 | nM | 7.75 | Biological Assay: Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm cult... | - |
| Fatty-acid amide hydrolase 1 | IC50 | = | 18.0 | nM | 7.75 | Biological Assay: Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm cult... | - |
| Fatty-acid amide hydrolase 1 | IC50 | = | 640.0 | nM | 6.19 | Inhibition of rat FAAH after 1 hr | 24900385 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900385 | 10.1021/ml300186g | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine