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Compound Detail

CHEMBL2165713

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CC1=C[C@]23C(=O)[C@@H](C=C(COC(=O)c4ccccc4)[C@@H](O)[C@]2(O)[C@H]1OC(=O)c1ccccc1)[C@H]1[C@@H](C[C@H]3C)C1(C)C

Basic Information

ChEMBL ID CHEMBL2165713
Phase Preclinical
Structure Type MOL
InChI Key GIMKEHNOTHXONN-NXBFFCPZSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

556.7
MW (Da)
4.54
ALogP
7
HBA
2
HBD
110.1
PSA (Ų)
0.41
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C34H36O7
MW 556.66
Aromatic Rings 2
Heavy Atoms 41
NP-Likeness 2.17

Activity Summary

EC50 3 meas. best 8.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 2
CHEMBL380
EC50 8.05 8.05 9.0 1
Human immunodeficiency virus 1
CHEMBL378
EC50 7.57 7.57 27.0 1
NON-PROTEIN TARGET
CHEMBL3879801
EC50 5.92 5.92 1200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25970561 10.1021/acs.jnatprod.5b00073 Unchecked 3
23062825 10.1016/j.bmc.2012.09.040 Acetylcholinesterase 1
23062825 10.1016/j.bmc.2012.09.040 Cholinesterase 1
25970561 10.1021/acs.jnatprod.5b00073 NON-PROTEIN TARGET 1
25970561 10.1021/acs.jnatprod.5b00073 Human immunodeficiency virus 1 1
25970561 10.1021/acs.jnatprod.5b00073 Human immunodeficiency virus 2 1

Data from ChEMBL 36 via Core Engine