Compound Detail
CHEMBL2177376
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C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCC(F)(F)F)c4ccc(Cl)cc4)CC3)c21
Basic Information
| ChEMBL ID | CHEMBL2177376 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RERSEUJKWZVXCS-ZTFGCOKTSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
497.9
MW (Da)
3.25
ALogP
6
HBA
2
HBD
81.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-gamma serine/threonine-protein kinase CHEMBL4816 | IC50 | 6.1 | 6.1 | 798.0 | 1 |
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 6.04 | 6.04 | 902.0 | 1 |
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | IC50 | 5.7 | 5.7 | 2005.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-gamma serine/threonine-protein kinase | IC50 | = | 798.0 | nM | 6.1 | Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tag... | 22934575 |
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 902.0 | nM | 6.04 | Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tag... | 22934575 |
| RAC-beta serine/threonine-protein kinase | IC50 | = | 2005.0 | nM | 5.7 | Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tag... | 22934575 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22934575 | 10.1021/jm301024w | RAC-alpha serine/threonine-protein kinase | 2 |
| 22934575 | 10.1021/jm301024w | Unchecked | 1 |
| 22934575 | 10.1021/jm301024w | RAC-beta serine/threonine-protein kinase | 1 |
| 22934575 | 10.1021/jm301024w | RAC-gamma serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine