Compound Detail
CHEMBL218803
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Basic Information
| ChEMBL ID | CHEMBL218803 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LFLZLNYRDAENMG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
419.6
MW (Da)
5.18
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.67
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 5.36 | 5.36 | 4360.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 5.0 | 5.0 | 10010.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 4360.0 | nM | 5.36 | Antiprotozoal activity against chloroquine-, pyrimethamine-resistant Plasmodium ... | 16889962 |
| Trypanosoma brucei rhodesiense | IC50 | = | 10010.0 | nM | 5.0 | Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 | 16889962 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16889962 | 10.1016/j.bmcl.2006.07.057 | Trypanosoma brucei rhodesiense | 1 |
| 16889962 | 10.1016/j.bmcl.2006.07.057 | Plasmodium falciparum | 1 |
| 16889962 | 10.1016/j.bmcl.2006.07.057 | L6 | 1 |
Data from ChEMBL 36 via Core Engine