Assay Detail
Functional
CHEMBL907006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.76 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.41 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 8.12 |
| CHEMBL387011 | — | — | 1 | 7.21 |
| CHEMBL216966 | — | — | 1 | 7.19 |
| CHEMBL376631 | — | — | 1 | 7.18 |
| CHEMBL384638 | — | — | 1 | 6.50 |
| CHEMBL218857 | — | — | 1 | 6.43 |
| CHEMBL220191 | — | — | 1 | 6.36 |
| CHEMBL219073 | — | — | 1 | 6.22 |
| CHEMBL375182 | — | — | 1 | 5.94 |
| CHEMBL374557 | — | — | 1 | 5.82 |
| CHEMBL219749 | — | — | 1 | 5.82 |
| CHEMBL219077 | — | — | 1 | 5.77 |
| CHEMBL375632 | — | — | 1 | 5.74 |
| CHEMBL427054 | — | — | 1 | 5.67 |
| CHEMBL374245 | — | — | 1 | 5.53 |
| CHEMBL385792 | — | — | 1 | 5.48 |
| CHEMBL386165 | — | — | 1 | 5.44 |
| CHEMBL374411 | — | — | 1 | 5.43 |
| CHEMBL219419 | — | — | 1 | 5.37 |
| CHEMBL219345 | — | — | 1 | 5.30 |
| CHEMBL375980 | — | — | 1 | 5.27 |
| CHEMBL414705 | — | — | 1 | 5.18 |
| CHEMBL425443 | — | — | 1 | 5.12 |
| CHEMBL373635 | — | — | 1 | 5.12 |
| CHEMBL216723 | — | — | 1 | 5.09 |
| CHEMBL384238 | — | — | 1 | 5.09 |
| CHEMBL374897 | — | — | 1 | 5.00 |
| CHEMBL218803 | — | — | 1 | 5.00 |
| CHEMBL373861 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL265502 | SURAMIN | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL387011 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL216966 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL376631 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL384638 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL218857 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL220191 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL219073 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL375182 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL374557 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL219749 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL219077 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL375632 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL427054 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL374245 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL385792 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL386165 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL374411 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL219419 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL219345 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL375980 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL414705 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL425443 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL373635 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL216723 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL384238 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL374897 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL218803 | — | IC50 | = | 10010.0 | nM | 5.00 |
| CHEMBL373861 | — | IC50 | = | 14230.0 | nM | 4.85 |
| CHEMBL385202 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL375535 | — | IC50 | = | 37940.0 | nM | 4.42 |
| CHEMBL220245 | — | IC50 | = | 37970.0 | nM | 4.42 |
| CHEMBL387170 | — | IC50 | - | — | - | |
| CHEMBL416956 | MEFLOQUINE | IC50 | - | — | - | |
| CHEMBL76 | CHLOROQUINE | IC50 | - | — | - | |
| CHEMBL269671 | ARTEMISININ | IC50 | - | — | - | |
| CHEMBL375622 | — | IC50 | - | — | - | |
| CHEMBL374898 | — | IC50 | - | — | - | |
| CHEMBL219455 | — | IC50 | - | — | - | |
| CHEMBL216655 | — | IC50 | - | — | - | |
| CHEMBL218805 | — | IC50 | - | — | - |